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Portable Network Graphic  |  1997-03-11  |  11KB  |  475x276  |  4-bit (3 colors)

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OCR: Pol Ymoiphis f position nine of the MHC class hea: chain affects the stability Of association -ith beta 2 -microglobulin and DIesentation of viral peptide Ribaudo and Margulies J Immunol 1995 To identify residues that control the between MHC- heavy chains and (bet 2m) sequence comparisons made between murine class I MHC molecules with high H-2Dd H-2Kb) and lo w (H-2Ld H-2Db) affinities for beta 2m single resii iue at position 9 evaluated for its to the stability of the complex Mutagenesis of the glutamic acid at position - ot H-2Ld valine is found in H-2Dd and H-2Kb resulted in both qualitative and q uantita ative on inter-chain intrace ellular transport, peptide binding and peptide presentation. In in vitro translation and assembly studies the E9V mutation : resulted in a more stable asso ...

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